How Much Do Genetics Matter in Sprinting?
July 17th, 2021Genetics clearly influence sprint performance—but by how much? There are several ways of answering this question. First, we can look for specific genetic variants that have an impact on performance. Second, we can estimate the heritability of speed or speed-related traits like muscular strength, height, and body type with twin and family studies. Finally, we can analyze the demographics of elite and sub-elite sprinters.
Genetic variants
Most of the literature focuses on two specific mutations: the ACTN3 R557R/X and ACE I/D variants.
ACTN3
ACTN3 encodes the α-actinin-3 protein, which is mostly restricted to Type II (fast-twitch) muscle fibers. Humans with the ACTN3 557XX genotype have no α-actinin-3 at all, and in fact appear to have a higher proportion of Type I (slow-twitch) muscle fibers than ACTN3 557RX or ACTN3 557RR humans. The obvious hypothesis, then, is that 577RR athletes should be better sprinters than 577XX athletes because of the existence of α-actinin-3 and a higher proportion of fast-twitch muscle fibers.